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Regenerative medicine may be a novel therapeutic option for treating xerostomia – a severe dry mouth condition, caused by the lack of production of appropriate amounts of saliva.  Patients who undergo radiation or chemotherapy treatments for neck and head cancers may develop xerostomia as a result of damaged salivary glands. Extreme dry mouth makes it difficult to speak or swallow, affecting a patient’s quality of life.

Typical treatments do not address the underlying issues of xerostomia and may only relieve symptoms temporarily. Regenerative medicine provides new therapeutic options.

Regenerative treatments may be able to help repair the neuronal and vascular structures that produce saliva due to the cell-to-cell interactions of the germ layers. Injected cells may work to either prevent damage from radiation or repair the damage created. Stem cells may provide an attractive approach to tissue regeneration in the glands by promoting healing, reducing inflammation and remodeling/repairing scarred tissue.

The first in-man implantation of stem cells to treat gland damage caused by cancer treatment was successfully performed and documented in a scientific paperco-authored by U.S. Stem Cell Clinic CSO Kristin Comella. The paper was published in the August 2017 issue of the International Medical Case Reports Journal.

The scientific paper was based on a case studyof a 54-year-old male with severe xerostomia post irradiation due to throat cancer, who demonstrated increased gland size, as calculated by ultrasound, with corresponding clinical response of increased saliva production after undergoing stem cell therapy. In addition, this case demonstrated the safety and feasibility of direct inject of stem cells in PRP in a severe xerostomia patient. The procedure was well tolerated and no major safety events were reported.

In the video below, Kristin talks more about the stem cell treatment of gland damage documented in the scientific paper and its results.

Adult stem cells are currently being studied for use in a variety of diseases and disorders, including xerostomia. Several preclinical animal studies have addressed the clinical benefits of mesenchymal stem cells (MSCs) on dysfunctional salivary glands. MSCs have a broad range of indications in various diseases or injuries due to their ability to repair damaged tissues or lesions. MSCs can multiply and form various tissue types representing a realistic biologic therapy. The MSCs may induce a paracrine effect leading to reduced inflammation, cell death, and tissue fibrosis. In addition, the regenerative potential of MSCs in radiation-damaged tissue is promising due to their relatively high radiation resistance.

Fat tissue has recently been established as a plentiful source of MSCs. In fact, approximately 500 times more stem cells can be obtained from fat than bone marrow.

Stem cells possess enormous regenerative potential. Our team has successfully treated over 7,000 patients with very few safety concerns reported. We are extremely encouraged by the positive patient results we are seeing from our physician-based treatments.  One day, stem cell treatments will be the gold standard of care for the treatment of most degenerative diseases.

To find out how regenerative medicine can help you improve your life, please request your free, no-obligation consultation on our website: or by calling 954-510-3150.

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