Limb ischemia

Autologous Adipose-derived Stromal Stem Cell Implantation to
Resolve Critical Limb Ischemia: Case Report

What’s important here?

Critical limb ischemia (CLI) is a debilitating condition for which limited therapeutic options exist. Characterized by ischemia of the lower limb due to vascular deficiency, attempts have been made to stimulate angiogenesis utilizing cell and gene-based approaches. Adipose stromal vascular fraction (SVF) cells are a practical source of autologous tissue that can be prepared inexpensively in a same-day procedure.

Wound healing  of radiation necrosis after stem cell treatments

New blood vessel supply after stem cell treatments



Recent studies have demonstrated SVF to be highly angiogenic, as well as clinically safe in a variety of contexts. Here, we describe the rationale and, to our knowledge, the first successful clinical implementation of autologous SVF cells for the treatment of a no-option CLI patient.